Palermo find themselves entirely cut adrift in 19th place in Serie A, with their relegation all but confirmed, while Fiorentina will be keen to take three points in the race for the Europa League.
La Viola are currently eight points off fifth-placed Atalanta with five games left to play, with it certainly not impossible for them to catch up if they can put some consistent results together.
The hosts are certainly better valued at Stadio Renzo Barbera, after picking up two draws and a win against 18th-placed Crotone in their last six home league games.
Fiorentina are fairly inconsistent away from home, but Paulo Sousa’s men do come into this game on a three-match unbeaten in the road, which includes two clean sheets.
The visitors will be high on confidence after participating in one of the most thrilling games of the season last time out, where Inter were disposed of by a 5-4 scoreline.
Viola may not be the best travellers in the division, but a need for three points combined by a far superior squad to Palermo can only point in one direction.