Real Madrid still have a game in hand on Barcelona but an El Clasico defeat last time out ensured that they have temporarily dropped back to second place in La Liga on goal difference.
Zinedine Zidane’s men have no option but to keep up the pace with victories until they get to play their extra match in May, with the title race suddenly much more open.
Pepe Mel’s side have won just one of their last six games, with their form taking a run for the worse after his initial positive impact on the club when he first arrived this year.
At Riazor, however, Real Madrid have lost just one of their last six, and have beaten Barcelona and drawn 1-1 with Atletico Madrid in the last month or so.
Sergio Ramos is suspended for the away side, with Raphael Varane likely to be rushed back to fitness for this week’s game. Zidane is expected to rotate fairly heavily after a tough last game.
Deportivo will fancy their chances of causing an upset at home, especially after beating Barcelona recently, but Real Madrid have plenty of second-string quality that will want to impress.