Atletico continue to string together an excellent run of form, both in La Liga and the Champions League, with Diego Simeone’s side also selling out Estadio Vicente Calderon regularly.
The hosts have kept a clean sheet in three of their last four competitive matches, and have even managed 1-1 draws away to the likes of Real Madrid and Leicester City recently.
Atletico have won eight of their last nine La Liga home games, scoring three goals in four of their last six matches. Antoine Griezmann is leading the charge and is the main threat.
Villarreal are in similarly good form in the league, but their prospects rely more heavily on playing their football at La Ceramica as they hunt for a top six finish.
Sime Vrsaljko and Juanfran are both out injured at right-back for the home side, but Jose Maria Gimenez deputized there in solid fashion versus Espanyol last week.
Given that Atletico are soon to be moving stadium, anything other than a home victory at Estadio Vicente Calderon is hard to imagine. Villarreal will have it tough.